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3500词第5轮打卡—熟词僻义5

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My assumptions rest on two guiding principles.划线处可以替换为? 
base on
base in
are based in
are based on
Winter has a sound grasp of these issues. 划线处可以替换为?
secure
thorough
deep
reliable
Unemployment among the over forties has risen sharply in recent years.划线部分的意思可以替换为?
clearly
abruptly
bitterly
smartly
The early success was succeeded by a period of miserable failure.与划线词意思最接近的是? 
follow
accompany
cause
gain